Response to vitamin E

Across TCGA patient cohorts, RNA activity of the Response to vitamin E pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAA15, NCL_S67, and TNS1_S1393, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin E activity versus NAA15 in HNSC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NAA15 →	-0.210	-0.073	<.001	.003	3	7
LUAD	NCL_S67 →	-0.685	-0.062	.001	<.001	3	7
BRCA	TNS1_S1393 →	+0.840	+0.060	<.001	.001	3	6
CCRCC	TNS2 →	+0.326	+0.081	.004	<.001	3	6
BRCA	TNS2_S102 →	+0.635	+0.067	.005	.001	3	6
BRCA	TOP1 →	-0.339	-0.068	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033197 vs NAA15 — HNSC

Explore this scatter interactively →