Response to vitamin E

Across TCGA cell cohorts, RNA activity of the Response to vitamin E pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLC1, PMM1, and CLSTN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLC1 grouped by Response to vitamin E-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MLC1 →	-0.732	-1.555	<.001	<.001	3	8
LUNG_NSCLC_LUSC	PMM1 →	-0.268	-1.523	.001	<.001	3	8
CNS	CLSTN2 →	-0.421	-1.570	<.001	<.001	3	7
CNS	CCR7 →	-0.443	-1.328	<.001	<.001	3	6
BLOOD_Myeloma	GPX1 →	-0.436	-2.273	.001	<.001	2	7
PANCREAS	CPXM1 →	-0.338	-1.135	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLC1 by Response to vitamin E activity — BLOOD_Leukemia

Explore this box plot interactively →