Response to vitamin E

Across TCGA cell cohorts, RNA activity of the Response to vitamin E pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, ALAD, and PLEKHM1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin E activity versus CAT in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CAT →	+1.286	+0.139	.004	.006	3	18
UPPER_AERODIGESTIVE_TRACT	ALAD →	+1.350	+0.175	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	PLEKHM1 →	+1.215	+0.166	<.001	<.001	3	10
BONE	GRN →	+1.623	+0.256	<.001	<.001	3	10
BONE	PLSCR4 →	+2.564	+0.217	<.001	<.001	3	9
BONE	SNX33 →	+1.671	+0.209	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033197 vs CAT — UPPER_AERODIGESTIVE_TRACT

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