Response to vitamin E

Across TCGA cell cohorts, RNA activity of the Response to vitamin E pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPX1, CAT, and COL1A1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin E activity versus GPX1 in BLOOD_Leukemia (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPX1 →	+1.812	+0.257	<.001	<.001	3	14
BLOOD_Leukemia	CAT →	+1.602	+0.213	<.001	<.001	3	11
CNS	COL1A1 →	+1.798	+0.406	<.001	.001	3	6
BLOOD_Leukemia	CD2BP2 →	-0.503	-0.287	<.001	<.001	3	4
BLOOD_Leukemia	COMT →	+0.808	+0.239	<.001	<.001	3	4
LUNG_SCLC	RPL7L1 →	+0.630	+0.895	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033197 vs GPX1 — BLOOD_Leukemia

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