Response to hydroperoxide

Across TCGA cell cohorts, RNA activity of the Response to hydroperoxide pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGD, SP140, and RBM20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGD grouped by Response to hydroperoxide-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PGD →	+1.216	+0.951	.001	<.001	3	4
LUNG_NSCLC_LUAD	SP140 →	-0.806	-0.639	<.001	.001	3	4
SOFT_TISSUE	RBM20 →	+1.715	+1.079	.001	.002	3	4
BREAST	FBXL5 →	-0.556	-0.300	.006	.009	3	4
LUNG_NSCLC_LUAD	VEGFD →	+0.427	+0.786	.004	<.001	3	3
LUNG_NSCLC_LUAD	CHCHD7 →	-0.857	-0.674	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGD by Response to hydroperoxide activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →