Response to hydroperoxide

Across TCGA cell cohorts, RNA activity of the Response to hydroperoxide pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX4, MT2A, and NIBAN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hydroperoxide activity versus PRDX4 in BREAST (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRDX4 →	-0.681	-0.873	.003	.004	3	6
OVARY	MT2A →	-2.208	-0.800	.003	.003	3	5
BLOOD_Lymphoma	NIBAN1 →	-3.031	-1.161	<.001	<.001	3	5
BLOOD_Leukemia	ZNF491 →	+0.674	+0.754	.001	.001	3	5
BLOOD_Leukemia	ZFP82 →	+1.692	+1.207	<.001	<.001	3	5
BLOOD_Lymphoma	ZYX →	-2.744	-1.244	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033194 vs PRDX4 — BREAST

Explore this scatter interactively →