Response to vitamin A

Across TCGA patient cohorts, RNA activity of the Response to vitamin A pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAAL1, TYMS, and ABLIM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin A activity versus SAAL1 in BRCA (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAAL1 →	+0.255	+0.036	.001	.003	3	4
GBM	TYMS →	+0.547	+0.059	.001	<.001	3	4
HNSC	ABLIM1 →	-0.282	-0.050	<.001	.004	3	4
BRCA	MDC1 →	+0.361	+0.050	<.001	.003	3	4
BRCA	WDHD1_S868 →	+0.529	+0.056	.008	.003	3	4
GBM	DHX16 →	+0.241	+0.080	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033189 vs SAAL1 — BRCA

Explore this scatter interactively →