Response to vitamin A

Across TCGA cell cohorts, RNA activity of the Response to vitamin A pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, SRCIN1, and RASGRP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin A activity versus CAT in LUNG_NSCLC_LUAD (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CAT →	+1.119	+1.109	<.001	.001	3	5
BONE	SRCIN1 →	-1.325	-0.288	.006	.004	3	5
LARGE_INTESTINE	RASGRP3 →	-2.129	-0.494	.002	.003	3	3
LUNG_NSCLC_LUAD	LAMA5 →	-1.037	-0.766	.003	.005	3	3
BLOOD_Leukemia	PIAS3 →	-0.830	-0.242	<.001	.003	3	3
LUNG_NSCLC_LUAD	PLPP1 →	+0.842	+0.597	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033189 vs CAT — LUNG_NSCLC_LUAD

Explore this scatter interactively →