Regulation of intracellular protein transport

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular protein transport pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, PNPT1, and MRPL38, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Regulation of intracellular protein transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAX →	-0.309	-0.041	.001	.002	3	7
OESOPHAGUS	PNPT1 →	-0.418	-0.062	.006	<.001	3	5
OESOPHAGUS	MRPL38 →	-0.304	-0.059	.008	.007	3	5
SOFT_TISSUE	STRN4 →	-0.467	-0.053	.001	.008	2	6
BLOOD_Myeloma	MAP3K8 →	-0.326	-0.044	<.001	<.001	3	5
LUNG_NSCLC_LUAD	WIPI2 →	-0.139	-0.056	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Regulation of intracellular protein transport activity — CNS

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