Regulation of intracellular protein transport

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular protein transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDS, FANCG, and VSIR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular protein transport activity versus IDS in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IDS →	+2.426	+0.147	<.001	.004	3	5
LIVER	FANCG →	+0.905	+0.137	.006	.007	2	5
URINARY_TRACT	VSIR →	+2.252	+0.151	.005	.006	3	4
STOMACH	TTC19 →	-1.019	-0.106	.008	.001	3	4
STOMACH	RDX →	+4.121	+0.171	.002	.001	3	4
LARGE_INTESTINE	MECP2 →	+0.940	+0.125	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033157 vs IDS — LARGE_INTESTINE

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