Immunoglobulin V(D)J recombination

Across TCGA patient cohorts, RNA activity of the Immunoglobulin V(D)J recombination pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASF1B, SLC41A2, and CD63, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunoglobulin V(D)J recombination activity versus ASF1B in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASF1B →	+0.490	+0.321	.003	<.001	3	4
LSCC	SLC41A2 →	-0.595	-0.437	.003	<.001	3	4
OV	CD63 →	-0.532	-0.555	<.001	<.001	3	4
BRCA	KIAA0513 →	-0.341	-0.309	.007	.009	3	4
BRCA	DPEP1 →	-0.443	-0.359	.003	.001	3	4
GBM	RMI2 →	+0.557	+0.749	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033152 vs ASF1B — LSCC

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