Immunoglobulin V(D)J recombination

Across TCGA cell cohorts, RNA activity of the Immunoglobulin V(D)J recombination pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf81, CSF1, and ENPP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2orf81 grouped by Immunoglobulin V(D)J recombination-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C2orf81 →	+1.115	+0.199	<.001	<.001	3	6
BREAST	CSF1 →	-2.162	-0.180	.006	.009	3	4
LUNG_NSCLC_LUAD	ENPP4 →	+1.267	+0.162	.001	.002	3	4
LARGE_INTESTINE	UGT8 →	+1.131	+0.162	.001	.003	3	4
BLOOD_Myeloma	AAR2 →	-1.025	-0.218	.006	.005	3	4
LUNG_SCLC	RINL →	+2.436	+0.298	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2orf81 by Immunoglobulin V(D)J recombination activity — URINARY_TRACT

Explore this box plot interactively →