Immunoglobulin V(D)J recombination

Across TCGA cell cohorts, RNA activity of the Immunoglobulin V(D)J recombination pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, IPO4, and PNRC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Immunoglobulin V(D)J recombination-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MDM2 →	-0.395	-0.147	<.001	<.001	3	4
BLOOD_Myeloma	IPO4 →	+0.406	+0.083	.009	.003	3	4
LUNG_NSCLC_LUSC	PNRC1 →	+0.226	+0.115	.005	<.001	3	4
BREAST	DBF4 →	+0.216	+0.080	<.001	.002	3	4
SOFT_TISSUE	CCND1 →	-0.560	-0.140	.004	.001	3	4
SOFT_TISSUE	SLC35A5 →	-0.338	-0.204	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Immunoglobulin V(D)J recombination activity — SOFT_TISSUE

Explore this box plot interactively →