Immunoglobulin V(D)J recombination

Across TCGA cell cohorts, RNA activity of the Immunoglobulin V(D)J recombination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMC2, PSIP1, and MTFR2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunoglobulin V(D)J recombination activity versus SMC2 in BLOOD_Myeloma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SMC2 →	+1.378	+0.441	.009	.008	2	9
BLOOD_Leukemia	PSIP1 →	+1.302	+0.282	<.001	<.001	3	8
KIDNEY	MTFR2 →	+1.267	+0.355	.001	<.001	3	8
LIVER	CENPH →	+0.882	+0.244	.007	.005	3	7
KIDNEY	NCAPH →	+1.314	+0.379	<.001	<.001	3	7
STOMACH	ANXA9 →	-2.565	-0.395	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033152 vs SMC2 — BLOOD_Myeloma

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