Negative regulation of intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELK3, HEG1, and PRICKLE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular estrogen receptor signaling pathway activity versus ELK3 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ELK3 →	+0.728	+0.316	<.001	<.001	3	4
CCRCC	HEG1 →	+0.488	+0.157	.001	.001	3	4
PDAC	PRICKLE2 →	+0.512	+0.113	<.001	.002	3	4
PDAC	DLC1 →	+0.451	+0.123	<.001	.001	3	4
PDAC	ANTXR1 →	+0.572	+0.106	<.001	.002	3	4
PDAC	TIMP2 →	+0.466	+0.105	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033147 vs ELK3 — OV

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