Negative regulation of intracellular estrogen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are L2HGDH, FAM220A, and RAB27A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, L2HGDH grouped by Negative regulation of intracellular estrogen receptor signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	L2HGDH →	+0.566	+0.322	.008	.008	3	4
UPPER_AERODIGESTIVE_TRACT	FAM220A →	-0.721	-0.218	.001	.001	3	4
LARGE_INTESTINE	RAB27A →	-0.610	-0.780	.001	.001	3	4
SKIN	MRPS18A →	+0.401	+0.204	.008	.006	3	4
BREAST	GRTP1 →	+1.489	+0.269	.002	.007	3	4
CNS	BMP1 →	-1.325	-1.202	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

L2HGDH by Negative regulation of intracellular estrogen receptor signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →