Negative regulation of intracellular estrogen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS18, TP53BP1, and SRCAP, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular estrogen receptor signaling pathway activity versus VPS18 in URINARY_TRACT (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	VPS18 →	+0.917	+0.125	<.001	<.001	3	18
STOMACH	TP53BP1 →	+1.141	+0.150	.003	.001	3	16
UPPER_AERODIGESTIVE_TRACT	SRCAP →	+1.546	+0.094	<.001	<.001	3	15
BLOOD_Lymphoma	UBTF →	+1.156	+0.076	<.001	<.001	3	15
SOFT_TISSUE	TNRC6B →	+1.134	+0.128	<.001	<.001	3	15
KIDNEY	CNP →	+0.976	+0.164	.003	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033147 vs VPS18 — URINARY_TRACT

Explore this scatter interactively →