Regulation of intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of intracellular estrogen receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, NASP, and CLTB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular estrogen receptor signaling pathway activity versus ADNP in LUAD (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADNP →	+0.254	+0.042	<.001	.005	3	5
LUAD	NASP →	+0.466	+0.046	<.001	.002	3	5
HNSC	CLTB →	-0.334	-0.079	<.001	.001	3	4
HNSC	HERC4 →	-0.130	-0.055	.003	.002	3	4
PDAC	UBXN7 →	+0.211	+0.034	<.001	<.001	3	4
UCEC	ADNP_S921 →	+0.401	+0.087	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033146 vs ADNP — LUAD

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