Regulation of intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM205, LINC02090, and AMBP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular estrogen receptor signaling pathway activity versus TMEM205 in COAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM205 →	+0.365	+0.472	.002	.003	3	3
COAD	LINC02090 →	-0.185	-0.530	.001	.001	3	3
BRCA	AMBP →	+0.604	+0.326	.006	.003	3	3
BRCA	SLC35F2 →	-0.685	-0.254	<.001	.001	3	3
BRCA	EFCC1 →	+1.195	+0.343	<.001	.005	3	3
UCEC	CACNA1D →	+0.904	+0.096	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033146 vs TMEM205 — COAD

Explore this scatter interactively →