Regulation of intracellular estrogen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFL1, GKAP1, and REPS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular estrogen receptor signaling pathway activity versus UFL1 in BLOOD_Myeloma (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	UFL1 →	+0.537	+0.234	.004	<.001	3	4
LUNG_NSCLC_LUSC	GKAP1 →	+1.857	+0.222	.005	.009	3	4
SOFT_TISSUE	REPS1 →	+1.252	+0.369	.008	<.001	3	4
BONE	HPS5 →	+0.927	+0.209	.006	<.001	3	3
BONE	GEM →	+2.994	+0.252	.006	.003	3	3
BONE	CD300LB →	-0.055	-0.211	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033146 vs UFL1 — BLOOD_Myeloma

Explore this scatter interactively →