Positive regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FOXA1_S331, ZYX, and LRCH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intracellular steroid hormone receptor signaling pathway activity versus FOXA1_S331 in BRCA (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXA1_S331 →	+1.263	+0.056	<.001	<.001	3	6
COAD	ZYX →	-0.281	-0.036	.003	.001	3	6
LUAD	LRCH1 →	-0.161	-0.049	<.001	<.001	3	6
COAD	SSRP1 →	+0.268	+0.038	.002	<.001	3	5
LSCC	RNF20 →	+0.234	+0.085	<.001	<.001	3	5
LSCC	SRA1 →	-0.168	-0.060	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033145 vs FOXA1_S331 — BRCA

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