Positive regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFMBT1, DNASE1, and PRRT1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFMBT1 grouped by Positive regulation of intracellular steroid hormone receptor signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SFMBT1 →	+0.904	+0.302	.003	.003	3	4
BLOOD_Leukemia	DNASE1 →	+1.120	+0.748	<.001	.009	3	4
BREAST	PRRT1B →	+1.045	+0.387	.001	<.001	3	4
BREAST	KIFC2 →	+1.515	+0.426	.001	.009	3	4
BREAST	TMEM141 →	+1.046	+0.485	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	DAP →	+1.589	+0.553	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFMBT1 by Positive regulation of intracellular steroid hormone receptor signaling pathway activity — OESOPHAGUS

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