Positive regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISYNA1, ADAM9, and TAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intracellular steroid hormone receptor signaling pathway activity versus ISYNA1 in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ISYNA1 →	+3.031	+0.703	<.001	.004	3	4
STOMACH	ADAM9 →	-1.402	-0.722	.001	.003	3	4
BLOOD_Lymphoma	TAP1 →	-1.808	-0.210	.002	.002	3	4
BLOOD_Lymphoma	P4HB →	-0.769	-0.161	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	COMMD10 →	+0.820	+0.689	.002	.009	3	3
STOMACH	SLC16A10 →	+1.417	+0.666	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033145 vs ISYNA1 — STOMACH

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