Negative regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, THBS3, and KANK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular steroid hormone receptor signaling pathway activity versus FSTL1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FSTL1 →	+0.757	+0.044	<.001	.006	3	8
BRCA	THBS3 →	+0.630	+0.046	<.001	<.001	3	7
HNSC	KANK2 →	+0.504	+0.077	<.001	<.001	3	7
BRCA	OLFML3 →	+0.711	+0.039	<.001	<.001	3	7
HNSC	NID1 →	+0.664	+0.083	<.001	<.001	3	7
BRCA	BGN →	+0.826	+0.050	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033144 vs FSTL1 — OV

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