Negative regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETD7, ICA1, and DTYMK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular steroid hormone receptor signaling pathway activity versus SETD7 in KIDNEY (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SETD7 →	-0.876	-0.165	.002	.008	3	3
OESOPHAGUS	ICA1 →	-2.040	-0.694	.002	.002	3	3
PANCREAS	DTYMK →	-0.668	-0.890	.009	.005	3	3
PANCREAS	TMEM199 →	-0.736	-0.764	<.001	.009	3	3
BLOOD_Leukemia	AKR1B1 →	-1.691	-0.423	.007	.008	3	3
BREAST	UTP18 →	-0.499	-0.599	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033144 vs SETD7 — KIDNEY

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