Regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG30, RBBP4, and FOXD3-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular steroid hormone receptor signaling pathway activity versus SNHG30 in LUAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNHG30 →	+0.584	+0.290	.004	.001	3	4
LUAD	RBBP4 →	+0.360	+0.225	.008	.006	3	4
HNSC	FOXD3-AS1 →	+0.710	+0.145	.001	.002	3	4
UCEC	RAP2B →	-1.332	-0.242	.001	.008	3	3
UCEC	LINC01503 →	-1.575	-0.242	.003	.008	3	3
UCEC	UQCRBP3 →	-0.539	-0.288	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033143 vs SNHG30 — LUAD

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