Regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTBP1, CXCL3, and CUX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTBP1 grouped by Regulation of intracellular steroid hormone receptor signaling pathway-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTBP1 →	-0.592	-0.068	.004	.003	3	5
LARGE_INTESTINE	CXCL3 →	+0.155	+0.064	.003	.001	3	4
LARGE_INTESTINE	CUX1 →	+0.106	+0.049	.003	<.001	3	4
BLOOD_Leukemia	LRRC3B →	-0.283	-0.055	.002	.002	3	4
LUNG_NSCLC_LUSC	FRMD5 →	+0.216	+0.039	.008	.004	1	6
URINARY_TRACT	GRK3 →	+0.385	+0.066	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTBP1 by Regulation of intracellular steroid hormone receptor signaling pathway activity — BLOOD_Lymphoma

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