Positive regulation of peptidyl-serine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, FKBP1A, and LAMA3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidyl-serine phosphorylation activity versus EGFR in BREAST (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EGFR →	+2.643	+0.778	.006	.003	3	8
SOFT_TISSUE	FKBP1A →	+1.093	+1.622	.002	<.001	3	6
LARGE_INTESTINE	LAMA3 →	+1.670	+0.613	.007	.008	2	6
SOFT_TISSUE	ITGA3 →	+4.739	+1.597	<.001	<.001	3	5
LUNG_SCLC	MAP4K1 →	+1.440	+0.662	.002	.003	3	5
SOFT_TISSUE	CATSPER1 →	+3.627	+1.394	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033138 vs EGFR — BREAST

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