Negative regulation of peptidyl-serine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-serine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, CYGB, and SYNPO, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-serine phosphorylation activity versus PRKG1 in UCEC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+0.663	+0.044	<.001	.002	3	8
HNSC	CYGB →	+0.498	+0.045	<.001	<.001	3	7
HNSC	SYNPO →	+0.504	+0.055	<.001	<.001	2	8
CCRCC	VCL →	+0.330	+0.042	<.001	<.001	3	7
CCRCC	DMD →	+0.302	+0.045	<.001	<.001	3	7
CCRCC	EHD3 →	+0.372	+0.045	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033137 vs PRKG1 — UCEC

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