Negative regulation of peptidyl-serine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-serine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DMTN_S372, DMTN_S226, and RBM33_S741, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-serine phosphorylation activity versus DMTN_S372 in PDAC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DMTN_S372 →	+1.180	+0.900	<.001	<.001	3	5
BRCA	DMTN_S226 →	+0.795	+0.188	<.001	<.001	3	4
OV	RBM33_S741 →	-0.785	-0.505	<.001	<.001	3	4
CCRCC	ZC3H13_S875 →	-0.328	-0.172	<.001	.001	3	4
PDAC	BPGM_T122 →	+0.744	+1.880	.002	.001	3	4
OV	VGLL4_S58 →	-1.675	-0.916	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033137 vs DMTN_S372 — PDAC

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