Negative regulation of peptidyl-serine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPDC7, RWDD2A, and VRK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEPDC7 grouped by Negative regulation of peptidyl-serine phosphorylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEPDC7 →	-0.991	-0.699	.005	.007	2	5
LUNG_NSCLC_LUAD	RWDD2A →	-0.751	-1.207	<.001	<.001	3	4
STOMACH	VRK2 →	+1.022	+1.523	.001	.001	3	4
LUNG_NSCLC_LUAD	KDELR3 →	-1.159	-1.007	.004	.003	2	4
OVARY	TOE1 →	+0.647	+1.251	.006	.001	3	3
KIDNEY	PIK3IP1 →	-2.242	-1.437	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEPDC7 by Negative regulation of peptidyl-serine phosphorylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →