Regulation of peptidyl-serine phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFAT5, DMXL1, and CEP350, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-serine phosphorylation activity versus NFAT5 in THYM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	NFAT5 →	+2.190	+0.042	<.001	<.001	3	33
UVM	DMXL1 →	+1.608	+0.034	<.001	<.001	3	33
UVM	CEP350 →	+1.245	+0.034	<.001	<.001	3	33
CHOL	NBEAL1 →	+1.421	+0.040	<.001	<.001	3	33
KIRC	LIMS1-AS1 →	+0.754	+0.036	<.001	<.001	3	33
CHOL	ZBED6 →	+2.065	+0.043	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033135 vs NFAT5 — THYM

Explore this scatter interactively →