Regulation of peptidyl-serine phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-serine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPING1, CNRIP1, and EHD3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-serine phosphorylation activity versus SERPING1 in GBM (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPING1 →	+0.619	+0.040	<.001	<.001	3	7
BRCA	CNRIP1 →	+0.565	+0.021	<.001	<.001	3	7
CCRCC	EHD3 →	+0.374	+0.028	.001	.003	3	7
LSCC	F11 →	+0.478	+0.035	<.001	<.001	3	7
COAD	ITIH3 →	+0.440	+0.016	.004	.004	3	7
BRCA	NID1 →	+0.357	+0.017	.007	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033135 vs SERPING1 — GBM

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