Regulation of peptidyl-serine phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MILR1, MBNL3, and TNIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MILR1 grouped by Regulation of peptidyl-serine phosphorylation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MILR1 →	+1.119	+0.714	.002	.001	3	5
LUNG_NSCLC_LUAD	MBNL3 →	+0.887	+0.658	<.001	<.001	3	5
SOFT_TISSUE	TNIP1 →	+2.014	+1.373	.002	<.001	3	5
LUNG_NSCLC_LUSC	STAP2 →	+2.723	+1.092	.001	.004	3	4
BLOOD_Myeloma	FLYWCH1 →	-1.520	-1.389	<.001	.001	3	4
CNS	SYNGR3 →	-1.001	-0.908	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MILR1 by Regulation of peptidyl-serine phosphorylation activity — CNS

Explore this box plot interactively →