Regulation of peptidyl-serine phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, LAMA3, and NIPAL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-serine phosphorylation activity versus EGFR in BREAST (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EGFR →	+2.861	+0.912	.004	.002	3	10
BREAST	LAMA3 →	+1.905	+0.805	.006	.006	3	6
SOFT_TISSUE	NIPAL3 →	+1.421	+1.396	.004	<.001	3	5
SOFT_TISSUE	C16orf74 →	+1.736	+1.094	.008	.003	3	5
PANCREAS	ZNF566 →	-0.918	-0.807	<.001	.007	3	5
SOFT_TISSUE	GRK3 →	-1.578	-1.391	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033135 vs EGFR — BREAST

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