Positive regulation of RNA splicing

Across TCGA cell cohorts, RNA activity of the Positive regulation of RNA splicing pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BU1, ZNF592, and PARG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2BU1 grouped by Positive regulation of RNA splicing-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2BU1 →	+0.573	+0.113	.006	.008	3	5
BREAST	ZNF592 →	+0.692	+0.134	.003	<.001	3	5
KIDNEY	PARG →	+0.819	+0.205	.001	<.001	3	4
BLOOD_Lymphoma	AGPAT4 →	+1.630	+0.269	.001	<.001	3	4
LARGE_INTESTINE	HPCA →	+0.929	+0.124	.002	.003	2	5
BREAST	ZNF501 →	+0.801	+0.100	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2BU1 by Positive regulation of RNA splicing activity — LARGE_INTESTINE

Explore this box plot interactively →