Positive regulation of RNA splicing

Across TCGA cell cohorts, RNA activity of the Positive regulation of RNA splicing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCC1, RRAS, and PARP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RNA splicing activity versus SMARCC1 in BREAST (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMARCC1 →	+0.771	+0.146	.003	.004	3	9
LIVER	RRAS →	-2.345	-0.225	<.001	<.001	3	8
OVARY	PARP1 →	+1.399	+0.296	.001	.005	3	7
OVARY	TGIF2 →	+1.558	+0.331	.001	.001	3	6
CNS	KLHDC3 →	+0.680	+0.209	.001	.005	3	6
BLOOD_Lymphoma	TMBIM1 →	-1.878	-0.184	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033120 vs SMARCC1 — BREAST

Explore this scatter interactively →