Mitochondrial respiratory chain complex assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial respiratory chain complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CKAP4_S26, RBMX_S352, and AKAP13_S650, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial respiratory chain complex assembly activity versus CKAP4_S26 in LUAD (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CKAP4_S26 →	-0.552	-0.028	.002	<.001	3	6
BRCA	RBMX_S352 →	+0.480	+0.021	<.001	<.001	3	6
BRCA	AKAP13_S650 →	-1.031	-0.026	.001	.002	3	6
BRCA	KIF1B_S1487 →	-0.649	-0.016	<.001	.006	3	6
GBM	LRRFIP1 →	-0.313	-0.041	.002	<.001	3	6
LSCC	PLIN3 →	-0.252	-0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033108 vs CKAP4_S26 — LUAD

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