Mitochondrial respiratory chain complex assembly

Across TCGA cell cohorts, RNA activity of the Mitochondrial respiratory chain complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIR, LTBP2, and CTDSP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSIR grouped by Mitochondrial respiratory chain complex assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VSIR →	-2.561	-0.305	.001	.009	3	4
LUNG_SCLC	LTBP2 →	-3.099	-0.408	<.001	.005	3	4
URINARY_TRACT	CTDSP1 →	-1.110	-0.423	.005	.009	3	4
CNS	PGF →	-1.959	-1.039	.002	.001	2	4
BREAST	GPR176 →	-1.654	-0.217	.001	.004	3	3
BREAST	PXDC1 →	-1.934	-0.279	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSIR by Mitochondrial respiratory chain complex assembly activity — LUNG_SCLC

Explore this box plot interactively →