Mitochondrial respiratory chain complex assembly

Across TCGA cell cohorts, RNA activity of the Mitochondrial respiratory chain complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARGC1B, DLL1, and KATNAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial respiratory chain complex assembly activity versus PPARGC1B in OESOPHAGUS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPARGC1B →	+1.045	+0.256	<.001	<.001	2	6
URINARY_TRACT	DLL1 →	+1.930	+0.341	.004	<.001	3	4
BLOOD_Leukemia	KATNAL1 →	-0.935	-0.585	.003	.006	3	4
LUNG_SCLC	SYNE3 →	-1.631	-0.182	<.001	.002	3	4
BLOOD_Leukemia	DNAJC5 →	-0.406	-0.617	.006	.004	3	4
LUNG_NSCLC_LUAD	RSPH1 →	+0.574	+0.189	.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033108 vs PPARGC1B — OESOPHAGUS

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