Positive regulation of immature T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of immature T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1B, PTAFR, and OSM, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of immature T cell proliferation activity versus IL1B in BLCA (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IL1B →	+2.360	+0.131	<.001	<.001	3	24
TGCT	PTAFR →	+1.098	+0.068	<.001	<.001	3	22
PCPG	OSM →	+1.176	+0.037	<.001	<.001	2	23
SKCM	LILRB1 →	+0.941	+0.042	<.001	<.001	3	22
DLBC	LCP2 →	+1.329	+0.096	.001	<.001	3	22
TGCT	BCL2A1 →	+1.260	+0.057	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033091 vs IL1B — BLCA

Explore this scatter interactively →