Positive regulation of immature T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of immature T cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CST8, COL8A1, and FLII, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CST8 grouped by Positive regulation of immature T cell proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CST8 →	-0.221	-0.952	.005	.005	3	4
SOFT_TISSUE	COL8A1 →	-0.184	-0.947	.009	.003	3	4
SOFT_TISSUE	FLII →	+0.300	+1.472	.002	.007	3	4
KIDNEY	LHFPL1 →	+0.754	+0.395	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	CABYR →	-0.161	-0.178	.007	.004	2	5
LARGE_INTESTINE	CITED2 →	+0.177	+0.216	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CST8 by Positive regulation of immature T cell proliferation activity — SOFT_TISSUE

Explore this box plot interactively →