Positive regulation of T cell differentiation in thymus

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOQ, BEST1, and IMPDH1P8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell differentiation in thymus activity versus RHOQ in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RHOQ →	+0.436	+0.357	.001	.007	3	4
PDAC	BEST1 →	+0.342	+0.297	<.001	<.001	3	3
PDAC	IMPDH1P8 →	-0.334	-0.287	<.001	<.001	3	3
BRCA	PSMB3P2 →	-0.072	-0.342	.006	.003	3	3
LSCC	ARHGEF39 →	-0.676	-0.386	<.001	.002	3	3
CCRCC	SIGLEC11 →	+0.428	+0.602	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033089 vs RHOQ — BRCA

Explore this scatter interactively →