Positive regulation of T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF234, LGALSL, and DLC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF234 grouped by Positive regulation of T cell differentiation in thymus-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF234 →	-1.880	-2.043	.001	<.001	3	4
OESOPHAGUS	LGALSL →	+1.141	+1.280	.003	.001	3	4
OESOPHAGUS	DLC1 →	-2.690	-1.231	.002	.002	2	5
OESOPHAGUS	CTAGE1 →	+0.056	+1.466	.004	<.001	3	4
LUNG_NSCLC_LUSC	CNOT10 →	-0.660	-1.435	.006	<.001	3	4
BREAST	CCAR2 →	-0.762	-0.791	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF234 by Positive regulation of T cell differentiation in thymus activity — BLOOD_Lymphoma

Explore this box plot interactively →