Negative regulation of immature T cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of immature T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN7, CEP112_S242, and ARHGAP23_S423, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of immature T cell proliferation activity versus SEPTIN7 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEPTIN7 →	+0.272	+0.111	<.001	<.001	3	4
BRCA	CEP112_S242 →	+0.758	+0.166	.001	<.001	3	4
CCRCC	ARHGAP23_S423 →	+0.602	+0.210	.001	<.001	3	4
OV	CDC42EP1 →	+0.450	+0.090	<.001	<.001	3	4
UCEC	TCF3 →	+0.372	+0.112	.001	.002	3	4
COAD	ERBB2 →	+0.237	+0.066	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033087 vs SEPTIN7 — OV

Explore this scatter interactively →