Negative regulation of immature T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of immature T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX8, ZBTB7C, and SLC3A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX8 grouped by Negative regulation of immature T cell proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SNX8 →	-1.456	-1.917	.001	<.001	3	5
OVARY	ZBTB7C →	-0.382	-0.992	.008	.001	3	4
LUNG_NSCLC_LUAD	SLC3A1 →	+0.526	+0.892	.002	.001	3	4
URINARY_TRACT	SLC39A9 →	-0.666	-1.888	.002	<.001	3	4
BREAST	H3C3 →	-0.632	-0.926	.005	.002	3	4
PANCREAS	LONRF2 →	+1.349	+1.121	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX8 by Negative regulation of immature T cell proliferation activity — LUNG_NSCLC_LUSC

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