Regulation of T cell differentiation in thymus

Across TCGA patient cohorts, RNA activity of the Regulation of T cell differentiation in thymus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COTL1, LCP1, and APOL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell differentiation in thymus activity versus COTL1 in OV (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COTL1 →	+0.685	+0.048	<.001	<.001	3	8
OV	LCP1 →	+0.761	+0.055	<.001	<.001	3	8
CCRCC	APOL3 →	+0.570	+0.065	<.001	<.001	3	8
OV	LAT_S224 →	+0.759	+0.041	<.001	<.001	3	7
PDAC	RCSD1_S179 →	+0.731	+0.068	<.001	<.001	3	7
BRCA	SEPTIN1 →	+0.678	+0.031	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033081 vs COTL1 — OV

Explore this scatter interactively →