Regulation of T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the Regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM22, PCED1B, and KRT6A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM22 grouped by Regulation of T cell differentiation in thymus-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RBM22 →	-0.608	-1.700	.004	<.001	3	4
OESOPHAGUS	PCED1B →	+1.368	+1.050	.003	.002	3	4
LUNG_NSCLC_LUSC	KRT6A →	+6.032	+1.225	.001	.007	3	4
KIDNEY	EEF1AKMT4 →	+0.969	+1.219	.002	.007	3	4
LARGE_INTESTINE	PKD2L1 →	+0.221	+0.954	.001	.002	3	3
LUNG_NSCLC_LUSC	FBXO5 →	-1.078	-1.818	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM22 by Regulation of T cell differentiation in thymus activity — SOFT_TISSUE

Explore this box plot interactively →