Regulation of T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the Regulation of T cell differentiation in thymus pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VARS1, DNM2, and COL4A5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VARS1 grouped by Regulation of T cell differentiation in thymus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VARS1 →	+0.323	+1.210	.005	.002	3	3
OESOPHAGUS	DNM2 →	-0.245	-1.293	.004	.008	3	3
LUNG_NSCLC_LUSC	COL4A5 →	-0.406	-1.583	.005	<.001	2	4
LUNG_NSCLC_LUSC	IFRD1 →	+0.320	+1.664	<.001	<.001	3	3
SOFT_TISSUE	DNAJC25-GNG10 →	+0.459	+1.585	.001	.001	2	4
SOFT_TISSUE	FOXD4L6 →	-0.370	-1.503	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VARS1 by Regulation of T cell differentiation in thymus activity — OVARY

Explore this box plot interactively →