Regulation of T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the Regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM50, NUMBL, and SOD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell differentiation in thymus activity versus TIMM50 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TIMM50 →	+0.440	+0.882	.009	.002	3	6
BLOOD_Leukemia	NUMBL →	+0.634	+0.604	<.001	.007	3	5
BLOOD_Lymphoma	SOD1 →	+0.886	+0.719	<.001	.007	3	5
BLOOD_Myeloma	AUNIP →	+0.894	+1.255	.001	.006	3	5
KIDNEY	ANKRD36 →	-1.277	-1.403	.007	<.001	3	4
BLOOD_Lymphoma	GEMIN7 →	+0.768	+1.107	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033081 vs TIMM50 — BREAST

Explore this scatter interactively →